Association of IRGM Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran

Table 2

The genotypes and allele distribution of IRGM polymorphisms in case and control groups.

Polymorphism	PTB n (%)	Control n (%)	OR (95%CI)	P	*OR (95%CI)	P
−1208 A/G (rs4958842)
AA	20 (13.3)	14 (9.3)	Ref.
AG	130 (86.7)	136 (90.7)	1.49 (0.73–3.08)	0.277	1.53 (0.74–3.18)	0.250
GG	0 (0.0)	0 (0.0)	—	—	—	—
Alleles
A	170 (56.7)	164 (54.7)
G	130 (43.3)	136 (45.3)	0.92 (0.67–1.27)	0.681
−1161 C/T (rs4958843)
TT	77 (51.3)	9 (6.0)	Ref.
CT	73 (48.7)	141 (94.0)	0.06 (0.03–0.12)	<0.001	0.06 (0.03–0.13)	<0.001
CC	0 (0.0)	0 (0.0)	—	—	—	—
Alleles
T	227 (75.7)	159 (53.0)
C	73 (24.3)	141 (47.0)	0.36 (0.26–0.51)	<0.001
−947 C/T (rs4958846)
TT	138 (92.0)	113 (75.3)	Ref.
CT	12 (8.0)	35 (23.4)	0.28 (0.14–0.57)	0.002	0.27 (0.13–0.55)	<0.001
CC	0 (0.0)	2 (1.3)	—	—	—	—
CT + CC	12	37 (24.66)	0.26 (0.13–0.53)	<0.001	0.26 (0.13–0.53)	<0.001
Alleles
T	288 (96.0)	261 (87.0)
C	12 (4.0)	39 (13.0)	0.27 (0.14–0.54)	<0.001

∗Adjusted for age and sex.