B Cell Responses to CpG Correlate with CXCL16 Expression Levels in Common Variable Immunodeficiency

Figure 4

Defective upregulation target genes (mRNA levels) after in vitro stimulation with CpG in CVID. (a) Fold increase of CD69, CD86, TLR9, AICDA, and IL-6 at the mRNA level after CpG stimulation. Experiments were performed with PBMCs in triplicates for all patients (𝑛=15) and healthy controls (𝑛=8). (b) Fold increase of TLR9, AICDA, and IL-6 at the mRNA level after CpG stimulation. Experiments were performed with purified B cells from patients (𝑛=4) and healthy controls (𝑛=2). Graph bars show standard error (SE).

(a)

(b)