Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats
Figure 3
Resting mean heart rate (min−1) in Wistar rats fed normocholesterolaemic diet. K_N: normocholesterolaemic control group, IW_N: normocholesterolaemic group receiving ivabradine, S1_N: normocholesterolaemic group receiving simvastatin at a dose of 1 mg × kg−1 bw, S20_N: normocholesterolaemic group receiving simvastatin at a dose of 20 mg × kg−1 bw, IW_N_S1: normocholesterolaemic group receiving ivabradine and simvastatin at a dose of 1 mg × kg−1 bw, IW_N_S20: normocholesterolaemic group receiving ivabradine and simvastatin at a dose of 20 mg × kg−1 bw, as compared to the control group, (a) as compared to rats receiving simvastatin alone, (b) as compared to rats receiving ivabradine alone, and (c) as compared to rats receiving ivabradine and simvastatin at a dose of 1 mg × kg−1 bw.