Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats

Figure 4

Resting mean heart rate (min⁻¹) in Wistar rats fed hypercholesterolaemic diet. K_H: hypercholesterolaemic control group, IW_H: hypercholesterolaemic group receiving ivabradine, S1_H: hypercholesterolaemic group receiving simvastatin at a dose of 1 mg × kg⁻¹ bw, S20_H: hypercholesterolaemic group receiving simvastatin at a dose of 20 mg × kg⁻¹ bw, IW_H_S1-hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 1 mg × kg⁻¹ bw, IW_H_S20: hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 20 mg × kg⁻¹ bw, ^∗𝑃<0.05 as compared to control group, (a) 𝑃<0.05 as compared to rats receiving simvastatin alone, and (b) 𝑃<0.05 as compared to rats receiving ivabradine alone, (c) 𝑃<0.05 as compared to rats receiving ivabradine and simvastatin at a dose of 1 mg × kg⁻¹ bw.