Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats

Table 2

Total cholesterol (TCH), HDL-cholesterol, LDL-cholesterol, and triglycerides (TGs) (mean ± SD) in rats fed hypercholesterolaemic diet (mmol/l).

	TCH	HDL	LDL	TGs
K_H (𝑛=10)	8,09 ± 1,53	0,36 ± 0,09	6,25 ± 0,65	3,24 ± 0,67
IW_H (𝑛=9)	7,53 ± 1,17	0,38 ± 0,11	5,98 ± 0,82	2,57 ± 0,11
S1_H (𝑛=8)	6,35 ± 1,81	0,61 ± 0,12*	4,45 ± 0,21*	2,82 ± 0,57
S20_H (𝑛=9)	2,01 ± 0,16*	0,42 ± 0,14*	1,29 ± 0,92*	0,65 ± 0,64*
IW_H_S1 (𝑛=8)	7,25 ± 0,67	0,69 ± 0,04*	4,94 ± 0,33*	3,50 ± 0,82
IW_H_S20 (𝑛=7)	1,34 ± 0,15*	0,33 ± 0,04*	0,16 ± 0,03*	0,96 ± 0,23*

K_H: hypercholesterolaemic control group, IW_H: hypercholesterolaemic group receiving ivabradine, S1_H: hypercholesterolaemic group receiving simvastatin at a dose of 1 mg × kg⁻¹ bw, S20_H: hypercholesterolaemic group receiving simvastatin at a dose of 20 mg × kg⁻¹ bw, IW_H_S1: hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 1 mg × kg⁻¹ bw, IW_H_S20: hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 20 mg × kg⁻¹ bw ^∗𝑃<0.05 as compared to the control group.