Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats

Table 4

Summary statistics (mean ± SD) for blood pressure (mmHg) in hypercholesterolaemic rats.

	Systolic blood pressure (mmHg)	Mean blood pressure (mmHg)	Diastolic blood pressure (mmHg)
K_H	107,77 ± 3,80	94,96 ± 3,73	85,86 ± 2,64
IW_H	105,46± 2,00	92,63 ± 2,75	86,38 ± 2,19
S1_H	105,47 ± 2,82	93,91 ± 4,14	85,20 ± 3,15
S20_H	106,81 ± 4,01	94,04 ± 3,20	85,32 ± 3,79
IW_H_S1	105,47 ±3,40	94,48 ± 4,19	86,48 ± 3,42
IW_H_S20	105,57 ± 3,43	93,95 ± 2,28	86,24 ± 4,33

K_H: hypercholesterolaemic control group, IW_H: hypercholesterolaemic group receiving ivabradine, S1_H: hypercholesterolaemic group receiving simvastatin at a dose of 1 mg × kg⁻¹ bw, S20_H: hypercholesterolaemic group receiving simvastatin at a dose of 20 mg × kg⁻¹ bw, IW_H_S1: hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 1 mg × kg⁻¹ bw, IW_H_S20: hypercholesterolaemic group receiving ivabradine and simvastatin at a dose of 20 mg × kg⁻¹ bw.