Influence of Codon Bias on Heterologous Production of Human Papillomavirus Type 16 Major Structural Protein L1 in Yeast

Table 1

Codon usage in HPV-16 L1-Sc, L1-Pl, L1-Ec, Li, L1-Hm, and L1-Pv ORFs.

Amino acids	Codons	Number of the indicated codons in the ORF
		L1-Pv	L1-Ec	L1-Pl	L1-Hm	L1-Sc
Ala	GCU	10	20	29		30
	GCC	6	4		30
	GCA	14		1
	GCG		6
Arg	AGA	4	1			19
	AGG	4		19	19
	CGU	2	13
	CGC	4	2
	CGA	4	1
	CGG	1	2
Asn	AAU	21		28		27
	AAC	7	28		28	1
Asp	GAU	18		27		27
	GAC	9	27		27
Cys	UGU	9	1	12		12
	UGC	3	11		12
Gln	CAA	11	19	19		19
	CAG	8			19
Glu	GAA	14	20	19		20
	GAG	6		1	20
Gly	GGU	15	32			35
	GGC	9	2		35
	GGA	8	1	35
	GGG	3
His	CAU	8		10		10
	CAC	2	10		10
Ile	AUU	12		21		22
	AUC		21	1	22
	AUA	10	1
Lys	AAA	27	32	34		34
	AAG	7	2		34
Leu	UUA	23	1
	UUG	5	1			43
	CUU	3		43
	CUC
	CUA	7	8
	CUG	5	33		43
Met	AUG	10	10	10	10	10
Phe	UUU	23	1	24		24
	UUC	1	23		24
Pro	CCU	17
	CCC	5			37
	CCA	15	3	37		37
	CCG		34
Ser	AGU	7	1
	AGC	2	2		33
	UCU	13	1			31
	UCC	4	23
	UCA	7	3	33		2
	UCG		3
Thr	ACU	14	2	41		41
	ACC	7	34		41
	ACA	19	3
	ACG	1	2
Trp	UGG	7	7	7	7	7
Tyr	UAT	15				22
	UAC	7	22	22	22
Val	GUU	17	30	32		32
	GUC	2	1
	GUA	10
	GUG	3	1		32