Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3

Figure 1

Block of mTRPV3 activity by icilin in oocytes. (a) A representative trace showing camphor, menthol, and 2-APB activation of mTRPV3, whereas icilin could not activate in Ca²⁺-containing SES. (b) A representative trace showing block of mTRPV3 activation by icilin in Ca²⁺-free SES. (c) Block of camphor-induced mTRPV3 currents by icilin. (d) Dose-dependent block of mTRPV3 by icilin in Ca²⁺-containing SES. (e) Inhibition curve for icilin’s IC₅₀ values. (f) Reversibility of inhibition of mTRPV3 by increasing 2-APB concentrations. (𝑛=6 in each case).

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