Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3

Figure 5

Original trace showing block of human TRPV3 by icilin. Since lower concentrations of icilin were not effective in case of hTRPV3 so higher doses were tested. 0.3 mM of icilin blocked ~50% of response induced by 10 mM 2-APB. The oocyte was preincubated in icilin before application of 2-APB. The experiment was carried out in Ca²⁺-free SES.