Genetic Structure and Expression of the Surface Glycoprotein GP82, the Main Adhesin of Trypanosoma cruzi Metacyclic Trypomastigotes
Figure 3
Comparison of GP82 mRNA post-transcriptional control mechanisms in (a) epimastigotes and (b) metacyclic trypomastigotes. In epimastigotes, GP82 mRNA interacts with possibly more than one RNA-binding protein (RBP), which binds to different cis-elements in the 3′UTR region (small black rectangles), leading to mRNA destabilization and decay. Conversely, in the metacyclic trypomastigote stage, a different set of RBPs interacts with the cis-elements present in the 3′UTR, promoting mRNA stabilization and translation in polysomes.
