Structure-Activity Relationships of 3,3′-Phenylmethylene-bis-4-hydroxycoumarins: Selective and Potent Inhibitors of Gram-Positive Bacteria
Figure 7
The stdev*coeff. contour maps. (a) and (b) represent CoMFA steric and electrostatic, respectively. (c) to (f) represent CoMSIA steric, electrostatic, hydrophobic, hydrogen bond donor, and hydrogen bond acceptor, respectively. Steric field is represented by green and yellow contour maps. Electrostatic field is represented by blue and red contour maps. Hydrophobic field is represented by orange and white contour maps. Hydrogen bond donor field is represented by cyan and purple contour maps. Hydrogen bond acceptor field is represented by magenta and red contour maps. All the contours represented the default 80% and 20% level contributions for favorable and unfavorable regions, respectively.
