A Local Genetic Algorithm for the Identification of Condition-Specific MicroRNA-Gene Modules

Algorithm 1

Pseudocode for module identification.

Input:   Parameter list of the genetic algorithm

    Parameter list of local search

    Score matrix ScoreM.

    Number of Modules ModN

Output: Module chromosomes M

Formal steps:

(1) Set 𝑚=0

(2) while  m != ModN do

(3)   Perform the genetic algorithm to identify co-expressed gene set and save to Gco

(4)   Apply the local search to Gco and save solution to M

(5)   Update PCC matrix

(6) end while

(7) Return M