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The Scientific World Journal
Volume 2013 (2013), Article ID 230176, 7 pages
http://dx.doi.org/10.1155/2013/230176
Research Article

Antitumor Activity of Human Hydatid Cyst Fluid in a Murine Model of Colon Cancer

1Laboratorio de Glicobiología e Inmunología Tumoral, Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay
2Clínica Quirúrgica 1, Hospital Pasteur, Facultad de Medicina, Universidad de la República, 11400 Montevideo, Uruguay
3Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República, 11400 Montevideo, Uruguay
4Unidad de Animales Transgénicos y Experimentación (UATE), Institut Pasteur de Montevideo, 11400 Montevideo, Uruguay

Received 5 June 2013; Accepted 14 July 2013

Academic Editors: T. T. Chye, M. C. Botelho, M. Gnanasekar, and N. Rout

Copyright © 2013 Edgardo Berriel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Ferlay, H.-R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. C. de Martel, J. Ferlay, S. Franceschi et al., “Global burden of cancers attributable to infections in 2008: a review and synthetic analysis,” The Lancet Oncology, vol. 13, pp. 607–615, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Fried, A. Reddy, and D. Mayer, “Helminths in human carcinogenesis,” Cancer Letters, vol. 305, no. 2, pp. 239–249, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Benamrouz, V. Conseil, C. Creusy, E. Calderon, E. Dei-Cas, and G. Certad, “Para-sites and malignancies, a review, with emphasis on digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa),” Parasite, vol. 19, pp. 101–115, 2012.
  5. B. J. Vennervald and K. Polman, “Helminths and malignancy,” Parasite Immunology, vol. 31, no. 11, pp. 686–696, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. W. B. Coley, “End results in Hodgkin's disease and lymphosarcoma treated by the mixed toxins of Erysipelas and Bacillus prodigiosus, alone or combined with radiation,” Annals of Surgery, vol. 88, pp. 641–667, 1928.
  7. R. J. Sylvester, “Bacillus Calmette-Guérin treatment of non-muscle invasive bladder cancer,” International Journal of Urology, vol. 18, pp. 113–120, 2011.
  8. E. C. Oliveira, M. S. B. Leite, J. A. R. Miranda et al., “Chronic Trypanosoma cruzi infection associated with low incidence of 1,2-dimethylhydrazine-induced colon cancer in rats,” Carcinogenesis, vol. 22, no. 5, pp. 737–740, 2001. View at Scopus
  9. L. Chen, Z. He, L. Qin et al., “Antitumor effect of malaria parasite infection in a murine lewis lung cancer model through induction of innate and adaptive immunity,” PLoS ONE, vol. 6, no. 9, Article ID e24407, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Akgül, M. Tez, A. E. Unal, M. Keşkek, I. Sayek, and T. Ozçelik, “Echinococcus against cancer: why not?” Cancer, vol. 98, pp. 1999–2000, 2003.
  11. F. van Knapen, “Echinococcus granulosus infection and malignancy,” British Medical Journal, vol. 281, no. 6234, pp. 195–196, 1980. View at Scopus
  12. E. Osinaga, “Expression of cancer-associated simple mucin-type O-glycosylated antigens in parasites,” IUBMB Life, vol. 59, no. 4-5, pp. 269–273, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Alvarez Errico, A. Medeiros, M. Míguez et al., “O-glycosylation in Echinococcus granulosus: identification and characterization of the carcinoma-associated Tn antigen,” Experimental Parasitology, vol. 98, no. 2, pp. 100–109, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Wadhwa, S. C. Kaul, Y. Ikawa, and Y. Sugimoto, “Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype,” Journal of Biological Chemistry, vol. 268, no. 9, pp. 6615–6621, 1993. View at Scopus
  15. R. Wadhwa, S. Takano, K. Kaur et al., “Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis,” International Journal of Cancer, vol. 118, no. 12, pp. 2973–2980, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. E. E. Gestl and S. Anne Böttger, “Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines,” Biochemical and Biophysical Research Communications, vol. 423, pp. 411–416, 2012. View at Publisher · View at Google Scholar
  17. S. L. Topalian, G. J. Weiner, and D. M. Pardoll, “Cancer immunotherapy comes of age,” Journal of Clinical Oncology, vol. 29, no. 36, pp. 4828–4836, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Mellman, G. Coukos, and G. Dranoff, “Cancer immunotherapy comes of age,” Nature, vol. 480, no. 7378, pp. 480–489, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. H. A. Aly, “Cancer therapy and vaccination,” Journal of Immunological Methods, vol. 382, pp. 1–23, 2012.
  20. H. Y. Darani and M. Yousefi, “Parasites and cancers: parasite antigens as possible targets for cancer immunotherapy,” Future Oncology, vol. 8, pp. 1529–1535, 2012.
  21. H. Yousofi Darani, N. Soozangar, S. Khorami, F. Taji, M. Yousofi, and H. Shirzad, “Hydatid cyst protoscolices induce cell death in WEHI-164 fibrosarcoma cells and inhibit the proliferation of baby hamster kidney fibroblasts in vitro,” Journal of Parasitology Research, vol. 2012, Article ID 304183, 4 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. M. S. Pidherney, H. Alizadeh, G. L. Stewart, J. P. McCulley, and J. Y. Niederkorn, “In vitro and in vivo tumoricidal properties of a pathogenic/free-living amoeba,” Cancer Letters, vol. 72, no. 1-2, pp. 91–98, 1993. View at Scopus
  23. V. D. Atayde, M. G. Jasiulionis, M. Cortez, and N. Yoshida, “A recombinant protein based on Trypanosoma cruzi surface molecule gp82 induces apoptotic cell death in melanoma cells,” Melanoma Research, vol. 18, no. 3, pp. 172–183, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. N. C. López, C. Valck, G. Ramírez et al., “Antiangiogenic and antitumor effects of Trypanosoma cruzi,” PLoS Neglected Tropical Diseases, vol. 4, no. 7, article e730, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. R. Baird, K. T. Byrne, P. H. Lizotte et al., “Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge,” The Journal of Immunology, vol. 190, pp. 469–478, 2013.
  26. S. Karadayi, S. Arslan, Z. Sumer, M. Turan, H. Sumer, and K. Karadayi, “Does hyda-tid disease have protective effects against lung cancer?” Molecular Biology Reports, 2013. View at Publisher · View at Google Scholar
  27. R. Rigano, E. Profumo, G. Di Felice, E. Ortona, A. Teggi, and A. Siracusano, “In vitro production of cytokines by peripheral blood mononuclear cells from hydatic patients,” Clinical and Experimental Immunology, vol. 99, no. 3, pp. 433–439, 1995. View at Scopus
  28. R. Riganò, E. Profumo, S. Ioppolo et al., “Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease,” Clinical and Experimental Immunology, vol. 102, no. 2, pp. 281–285, 1995. View at Scopus
  29. J. H. C. Kanan and B. M. Chain, “Modulation of dendritic cell differentiation and cytokine secretion by the hydatid cyst fluid of Echinococcus granulosus,” Immunology, vol. 118, no. 2, pp. 271–278, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Lorenzo, J. A. Last, and G. G. González-Sapienza, “The immunogenicity of Echinococcus granulosus antigen 5 is determined by its post-translational modifications,” Parasitology, vol. 131, no. 5, pp. 669–677, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. G. González-Sapienza and R. E. Cachau, “Identification of critical residues of an immunodominant region of Echinococcus granulosus antigen B,” Journal of Biological Chemistry, vol. 278, no. 22, pp. 20179–20184, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. S. R. Dundas, L. C. Lawrie, P. H. Rooney, and G. I. Murray, “Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival,” Journal of Pathology, vol. 205, no. 1, pp. 74–81, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Sherman and G. Multhoff, “Heat shock proteins in cancer,” Annals of the New York Academy of Sciences, vol. 1113, pp. 192–201, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. A.-L. Joly, G. Wettstein, G. Mignot, F. Ghiringhelli, and C. Garrido, “Dual role of heat shock proteins as regulators of apoptosis and innate immunity,” Journal of Innate Immunity, vol. 2, no. 3, pp. 238–247, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. F. Mühlschlegel, P. Frosch, A. Castro, H. Apfel, A. Müller, and M. Frosch, “Molecular cloning and characterization of an Echinococcus multilocularis and Echinococcus granulosus stress protein homologous to the mammalian 78 kDa glucose regulated protein,” Molecular and Biochemical Parasitology, vol. 74, no. 2, pp. 245–250, 1995. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Ortona, P. Margutti, F. Delunardo et al., “Molecular and immunological characterization of the C-terminal region of a new Echinococcus granulosus Heat Shock Protein 70,” Parasite Immunology, vol. 25, no. 3, pp. 119–126, 2003. View at Publisher · View at Google Scholar · View at Scopus