Substrains of Inbred Mice Differ in Their Physical Activity as a Behavior

Figure 2

Kinetics of physical activity in healthy and C26-bearing BALB/c AnNCrl mice. Seven-week-old female BALB/c AnNCrl mice were individually placed in wheel equipped cages. At the same time a group (C26 bearing) was subcutaneously transplanted with the C26 colon carcinoma to induce muscle wasting. The running distance was daily recorded and averaged among replicates from at least three independent experiments. Both healthy and diseased mice do exercise, even though C26-bearing mice run for up to 6 Km/day, while healthy mice increased the daily distance run on the wheel to 11 Km/day. *P < 0.01 by Tukey’s HSD test versus C26-bearing mice.