The Anticonvulsant Enaminone E139 Attenuates Paclitaxel-Induced Neuropathic Pain in Rodents
Figure 5
Effect of treatment with E139 on paclitaxel-induced mechanical allodynia in Sprague Dawley rats. (a) Time course of the withdrawal threshold to the dynamic plantar aesthesiometer after administration of paclitaxel 16 mg/kg or its vehicle on two alternate days. Each point represents the mean ± S.E.M of values obtained from 9 animals. and compared to drug vehicle at the same day after treatment (two-way repeated measures ANOVA followed by Bonferroni test) and compared to pretreatment (PRE) values (one-way ANOVA followed by Dunnett’s multiple comparison test). (b) Percentage change in withdrawal threshold from baseline values (taken at day 7 after first administration of paclitaxel) at 2 and 24 h after each treatment with E139 (10 and 20 mg/kg) or its vehicle using a dynamic plantar aesthesiometer. E139 was administered in 4 daily doses. Each bar represents the median values with interquartile range of values obtained from 16 to 17 animals. and compared to drug vehicle at the same time point after treatment (Kruskal-Wallis test).
