The Clinical Efficiency of Positive Airway Pressure Treatment

Koseoglu, Sabri; Ikinciogullari, Aykut; Cetin, Mehmet Ali; Saygi Uysal, Gokce; Kum, Rauf Oguzhan; Arli, Berna

doi:https://doi.org/10.1155/2013/245476

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Clinical Study | Open Access

Volume 2013 | Article ID 245476 | https://doi.org/10.1155/2013/245476

The Clinical Efficiency of Positive Airway Pressure Treatment

Sabri Koseoglu,¹Aykut Ikinciogullari,¹Mehmet Ali Cetin,¹Gokce Saygi Uysal,²Rauf Oguzhan Kum,¹and Berna Arli³

Academic Editor: K. M. Ozcan, I. Ozcan, A. Selcuk, S. Cureoglu

Received04 Mar 2013

Accepted28 Mar 2013

Published29 Apr 2013

Abstract

Objectives. The aim of this study was to evaluate the clinical efficiency and compliance of positive airway pressure (PAP) treatment. Materials and Methods. This study was conducted on moderate-severe obstructive sleep apnea syndrome (OSAS) patients who admitted to Ankara Numune Hospital Sleep Center between 2008 and 2012. Seventy-five patients with moderate-severe OSAS who were using PAP treatment regularly were enrolled in the study. Patient's usage data, Epworth sleepiness scale (ESS) scores, and the differences in complaints of OSAS were recorded. Results. The overall complaints were improved when compared to pretreatment period. Particularly there was improvement in apnea, snoring, excessive daytime sleepiness, fatigue, and sleep quality. Conclusion. PAP is effective in reducing symptoms in people with moderate and severe OSAS. To inform the patients with details and the creation of strategies for close followup are necessary for improving the compliance of the patients. Trial registration number: ACTRN12613000373774.

1. Introduction

Positive airway pressure (PAP) is the first line treatment of moderate and severe obstructive sleep apnea syndrome (OSAS). Disturbance of sleep quality, excessive daytime sleepiness, apnea, deterioration of life quality, and also the presence of cardiovascular, metabolic, neuropsychiatric, and urogenital disorders such as hypertension, diabetes mellitus, dislipidemia, metabolic syndrome, panic attack, depression, stroke, and erectil dysfunction show the importance of the treatment [1–7]. Previous studies showed that PAP treatment improves the symptoms of OSAS, rate of comorbid disorders, cardiovascular morbidity, and mortality. The positive consequences of PAP treatment result higher compliance of patients [1–6, 8].

PAP compliance is the ratio of the patients that use the treatment regularly to the total number. Compliance problem is frequently encountered in OSAS patients. Some publications notified that 29–48.2% of the patients do not use the PAP treatment [8, 9]. The adverse effects such as difficulty to exhale against positive pressure, skin reactions, unfit or very tight mask, nasal blockage, dryness of throat, and aerophagia are among the factors that affect the compliance negatively [10].

The aim of this study was to evaluate the knowledge of patients about the usage of device, problems encountered during the usage of device, Epworth sleepiness scale (ESS), comparison of the complaints of the patients before and after the usage of device, and the alterations of nocturia by questionnaires.

2. Materials and Methods

This study was conducted on moderate-severe OSAS patients who admitted to Ankara Numune Education and Research Hospital Sleep Center between 2008 and 2012. Patients with apnea hypopnea index (AHI) above 15 measured by all night polysomnographic studies (PSG) were enrolled to the study. PSG was performed during patients’ spontaneous sleep with the supervision of a technician. Electroencephalogram (EEG), electromyogram (EMG-submental and left-right tibialis anterior), electrooculogram (EOG, left-right), nasal airflow, thoracic and abdominal respiratory effort, blood oxygen saturation (by pulse oximetry), and body positions were recorded all night long. These data were also scored manually by using Alice PSG system by an ENT physician with a sleep certificate.

Moderate-severe OSAS patients with AHI >15 were informed in detail about the risk of their disease, possible morbidity and mortality, and the importance of treatment before titration. This information was given by the experienced ENT physicians who performed the PSG scoring.

Among these, 153 of patients performed automatic positive airway pressure titration all night long. Titration data was scored manually. Automatic positive airway pressure (APAP) device was given to supine-dependent and/or rapid-eye-movement- (REM-) dependent patients, and bilevel positive airway pressure (BiPAP) device was given to patients with pressure above 12 cm H₂O in automatic PAP titration, chronic obstructive lung disease, and/or obesity hypoventilation syndrome, and (continuous positive airway pressure) CPAP was given to other patients.

As 35 of the patients could not be reached, they were excluded from the study. Total 118 patients were reached, and informed consent were taken.

43 patients (43/118, 36.5%) did not use PAP treatment. 75 patients (75/118, 63.5%) kept going on with PAP treatment.

75 patients who were using PAP treatment regularly were enrolled in the study. Patient’s usage data, ESS scores, and the differences in complaints of OSAS were recorded (Table 1).

Control examination of patients was performed, and the routines of device usage and usage time (Table 1), problems encountered during the usage of device (Table 2), Epworth sleepiness scale (ESS), and comparison of the discrepancy of complaints before and after the usage of device were evaluated with questionarries. In Table 3, patients were asked to score the discrepancies of their complaints considering their state prior to treatment with worse (−2), bad (0), good (), or better ().

3. Results

49 (65.3%) of the 75 patients were males and 26 (34.7%) were females. Their mean age was (35–84).

The mean usage time of device was (6–30) months. Mean orientation time of the patients to the device was detected as 10.5 days (1–90 day). The mean usage time of the device was 6.3 days (4–7). The mean daily usage time was 6.7 (4–10) hours.

Patients were asked if the device pressure was sufficient or not, and it was revealed that 65 of the patients (86.6%) found it sufficient, 8 (10.6%) of them found more, and 2 (2.6%) of them found less.

The ratio of the patients and bed partners who were disturbed from the voice of the device was found to be 24/75 (32%).

It was seen that nocturia was reduced in 36 (48%) of the patients, no change in 38 (50.6%) patients, and increased in 1 (1.3%) patient after starting to use the device.

Problems encountered while using the device were investigated. According to this, most common complaint was dryness of throat (34/75) and then leakage from mask (22/75), nasal blockage (21/75), and excessive noise arising from device (17/75). The problems the patients encountered during the usage of device were summarized in Figure 1.

ESS scores of the enrolled patients were shown in Figure 2. When the patients were evaluated according to their mean ESS score, it was found as 5.4. Excessive daytime sleepiness was finished according to ESS.

Symptoms of patients going on PAP treatment were evaluated before and after the treatment. The results were shown in Figure 3. The overall complaints were improved comparing to pretreatment period. The symptoms with apparent improvement and number of patients were shown in Figure 4. Particularly there was improvement in apnea, snoring, excessive daytime sleepiness, fatigue, and sleep quality.

4. Discussion

PAP treatment is a golden standard therapy method of moderate and severe OSAS [11]. The compliance is low although the results of the treatment are very good. There are variable compliance ratios reported in PAP treatment studies for compliance. In recent studies, it was seen that the compliance increased [12], but in long-term follow-up studies, it was revealed that the compliance decreased [13]. In this study the compliance ratio was found as 63.5% and the mean usage time as 15.1 months.

The daily usage time among the patients who are going on PAP treatment is reported as 4.7–5.6 h/d [14, 15]. In this study, it was found as 6.7 h/d.

Throat dryness, leakage from mask, rubbing, nasal blockage, and the noise of the device are the most common problems of the patients who are going on treatment [15]. Also, in this study, throat dryness was found to be the most common adverse effect of the treatment.

It was reported that psychiatric problems such as depression incidence are low in long-term usage [7]. Also, in this study, there was improvement in depression and anxiety in 18 (24%) of the patients.

It was known that the blood pressure is reduced with CPAP treatment in hypertension and OSAS patients [16]. In this study, it was detected that blood pressure levels were better with PAP treatment in 26 (34.6%) of the patients.

ESS is a common method to evaluate the excessive daytime sleepiness all around the world. Ozcan et al. revealed that although ESS is not beneficial to determine the excessive daytime sleepiness, the answers of patients can be influenced by the differences between the socioculturel and economic conditions. Therefore, the necessity to create new forms for each country according to their sociocultural and economic conditions was emphasized [17]. Overall, scores below 10 were accepted as normal, above 10 as excessive daytime sleepiness, and above 16 as severe excessive daytime sleepiness [18]. In this study, mean ESS score of the patients was found to be 5.4, so it was concluded that no one has excessive daytime sleepiness.

It was reported that there was a reduction in chronic fatigue and nocturia and improvement in sexual function and life quality [19, 20]. In this study, there was a reduction in snoring (58, 77.3%), reduction in fatigue (47, 62%), and reduction in nocturia (36, 48%). It was detected that there was an improvement in sexual function (23, 30%) and sleep quality (56, 74.6%). When compared to pretreatment period, significant improvement and recovery were observed in most of the symptoms.

As a result, PAP treatment has recoverable and tolerable adverse effects. PAP treatment maintain a significant improvement in sleep and life quality. It was revealed that PAP treatment has a significant recovery on the symptoms of OSAS and related diseases. To inform the patients with details and the creation of strategies for close followup are necessary for improving the compliance of the patients.

References

N. S. Marshall, K. K. H. Wong, P. Y. Liu, S. R. J. Cullen, M. W. Knuiman, and R. R. Grunstein, “Sleep apnea as an independent risk factor for all-cause mortality: the busselton health study,” Sleep, vol. 31, no. 8, pp. 1079–1085, 2008.
View at: Google Scholar
J. M. Marin, S. J. Carrizo, E. Vicente, and A. G. N. Agusti, “Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study,” The Lancet, vol. 365, no. 9464, pp. 1046–1053, 2005.
View at: Publisher Site | Google Scholar
M. Fusetti, A. B. Fioretti, M. Valenti et al., “Cardiovascular and metabolic comorbidities in patients with obstructive sleep apnoea syndrome,” Acta Otorhino-Laryngologica Italica, vol. 32, no. 5, pp. 320–325, 2012.
View at: Google Scholar
Y. Takaesu, Y. Inoue, Y. Komada et al., “Effects of nasal continuous positive airway pressure on panic disorder comorbid with obstructive sleep apnea syndrome,” Sleep Medicine, vol. 13, no. 2, pp. 156–160, 2012.
View at: Publisher Site | Google Scholar
M. Á. Martínez-García, J. J. Soler-Cataluña, L. Ejarque-Martínez et al., “Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study,” American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 1, pp. 36–41, 2009.
View at: Publisher Site | Google Scholar
T. Santos, M. Drummond, and F. Botelho, “Erectile dysfunction in obstructive sleep apnea syndrome—prevalence and determinants,” Revista Portuguesa de Pneumologia, vol. 18, no. 2, pp. 64–71, 2012.
View at: Publisher Site | Google Scholar
J. D. Edinger, S. Carwile, P. Miller, V. Hope, and C. Mayti, “Psychological status, syndromatic measures, and compliance with nasal CPAP therapy for sleep apnea,” Perceptual and Motor Skills, vol. 78, no. 3, pp. 1116–1118, 1994.
View at: Google Scholar
S. Olsen, S. Smith, and T. P. S. Oei, “Adherence to continuous positive airway pressure therapy in obstructive sleep apnoea sufferers: a theoretical approach to treatment adherence and intervention,” Clinical Psychology Review, vol. 28, no. 8, pp. 1355–1371, 2008.
View at: Publisher Site | Google Scholar
M. Uyar, O. Elbek, A. Mete et al., “Factors influencing compliance with continuous positive airway pressure ventilation in obstructive sleep apnea syndrome,” Tüberküloz ve Toraks, vol. 60, pp. 47–51, 2012.
View at: Publisher Site | Google Scholar
J. L. Pepin, P. Leger, D. Veale, B. Langevin, D. Robert, and P. Levy, “Side effects of nasal continuous positive airway pressure in sleep apnea syndrome: study of 193 patients in two French sleep centers,” Chest, vol. 107, no. 2, pp. 375–381, 1995.
View at: Google Scholar
D. I. Loube, P. C. Gay, K. P. Strohl, A. I. Pack, D. P. White, and N. A. Collop, “Indications for positive airway pressure treatment of adult obstructive sleep apnea patients: a consensus statement,” Chest, vol. 115, no. 3, pp. 863–866, 1999.
View at: Publisher Site | Google Scholar
D. Ghosh, V. Allgar, and M. W. Elliott, “Identifying poor compliance with CPAP in obstructive sleep apnoea: a simple prediction equation using data after a two week trial,” Respiratory Medicine, 2012.
View at: Publisher Site | Google Scholar
C. Alves, J. M. P. C. Caminha, A. M. da Silva, and D. Mendonça, “Compliance to continuous positive airway pressure therapy in a group of Portuguese patients with obstructive sleep apnea syndrome,” Sleep and Breathing, vol. 16, no. 2, pp. 555–562, 2011.
View at: Publisher Site | Google Scholar
W. Galetke, L. Puzzo, C. Priegnitz, N. Anduleit, and W. J. Randerath, “Long-term therapy with continuous positive airway pressure in obstructive sleep apnea: Adherence, side effects and predictors of withdrawal-a “real-life” study,” Respiration, vol. 82, no. 2, pp. 155–161, 2011.
View at: Publisher Site | Google Scholar
S. Yurtlu, N. Sariman, E. Levent et al., “Short-term positive airway pressure therapy response in obstructive sleep apnea patients: impact of treatment on the quality of life,” Tüberküloz ve Toraks, vol. 60, no. 4, pp. 327–335, 2012.
View at: Google Scholar
F. Campos-Rodriguez, J. Perez-Ronchel, A. Grilo-Reina, J. Lima-Alvarez, M. A. Benitez, and C. Almeida-Gonzalez, “Long-term effect of continuous positive airway pressure on BP in patients with hypertension and sleep apnea,” Chest, vol. 132, no. 6, pp. 1847–1852, 2007.
View at: Publisher Site | Google Scholar
K. M. Ozcan, T. Ozdas, F. Ozdogan et al., “Inconsistency of the Epworth sleepiness scale results with the polysomnography findings in patients with sleep-disordered breathing,” Kulak Burun Bogaz Ihtis Derg, vol. 22, no. 4, pp. 195–199, 2012.
View at: Google Scholar
J. Rey de Castro and E. Rosales-Mayor, “Clinical and polysomnographic differences between OSAH patients with/without excessive daytime sleepiness,” Sleep Breath. In press.
View at: Google Scholar
I. A. C. Cruz, M. Drummond, and J. C. Winck, “Obstructive sleep apnea symptoms beyond sleepiness and snoring: effects of nasal APAP therapy,” Sleep and Breathing, vol. 16, no. 2, pp. 361–366, 2012.
View at: Publisher Site | Google Scholar
H. M. Engleman, R. N. Kingshott, P. K. Wraith, T. W. Mackay, I. J. Deary, and N. J. Douglas, “Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep apnea/hypopnea syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 159, no. 2, pp. 461–467, 1999.
View at: Google Scholar

Copyright

Copyright © 2013 Sabri Koseoglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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