Renin and the IGFII/M6P Receptor System in Cardiac Biology

Table 1

Selected examples of the effect of pharmacological intervention at various sites of the RAAS on plasma renin concentration.

Species	Site of inhibition	Renin concentration		References
		Basal	Treatment
Human	Renin (aliskiren)	14.9 mU/L	48.4 mU/L	[5]
Human	ACE (ramipril)	14.4 mU/L	35.2 mU/L	[5]
Human	AT1 (irbesartan)	17 mU/L	56 mU/L	[6]
Human	Renin (aliskiren)	5.6 pg/mL	34.9 pg/mL*	[7]
Human	AT1 (irbesartan)	5.6 pg/mL	11.3 pg/mL	[7]
Rat (SHR)	Renin (aliskiren)	9.3±0.9 mg/kg	11.3±1.9 mg/kg	[8]
Rat (SHR)	ACE (captopril)	9.3±0.9 mg/kg	87.1±61.0 mg/kg*	[8]
Rat (SHR)	ACE (captopril)	6.3±1.6 ng/mL	27.4±6.7 ng/mL*	[9]
Rat (SHR)	AT1 (irbesartan)	9.3±0.9 mg/kg	143.0±33.5 mg/kg*	[8]
Mouse (ApoE^−/−)	Renin (aliskiren)	755±90 ng/mL	3760±567 mg/mL	[10]
Mouse (ApoE^−/−)	AT1 (irbesartan)	755 ng/mL	11235±3001 ng/mL	[10]