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The Scientific World Journal
Volume 2013 (2013), Article ID 274643, 7 pages
http://dx.doi.org/10.1155/2013/274643
Research Article

Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

Larissa Lavorato Lima,1 Rebeca Mól Lima,2 Annelisa Farah da Silva,2 Antônio Márcio Resende do Carmo,3 Adilson David da Silva,1 and Nádia Rezende Barbosa Raposo2

1Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
2Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil
3Faculdade de Odontologia, Universidade Federal de Juiz de Fora, Campus Universitário, 36036-900 Juiz de Fora, MG, Brazil

Received 7 November 2012; Accepted 14 January 2013

Academic Editors: Hélène Pellissier, Georgiy B. Shul'pin, and Ying-Wei Yang

Copyright © 2013 Larissa Lavorato Lima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This research has been an effort to develop synthetic resveratrol analogs in order to improve the depigmenting potential of natural resveratrol. Six resveratrol analogs were synthesized and tested for tyrosinase inhibitory activity in vitro, by qualitative and quantitative steps. The results showed the analog C as being the most powerful tyrosinase inhibitor (IA50 = 65.67 ± 0.60 μg/mL), followed by the analogs B, E, F, A, and D, respectively. The analog C presented a tyrosinase inhibition potential better than natural resveratrol ( ). The best depigmenting activity was provided by the presence of hydroxyl in the orthoposition on the second phenolic ring.