Azastilbene Analogs as Tyrosinase Inhibitors: New Molecules with Depigmenting Potential

Table 2

Tyrosinase inhibitory activity of new molecules and kojic acid.

Analogs (𝑛=6)	Chemical structure	IA 60 min (%)	IA 120 min (%)	IA50 (µg·mL^−1)
A		87.83 ± 1.50^a	85.60 ± 0.61^h	95.57 ± 0.74^p
B		82.37 ± 1.18^b	81.50 ± 0.50^i	70.60 ± 1.22^p,q
C		77.43 ± 0.59^a,c	74.57 ± 0.65^h,j	65.67 ± 0.60^p,r
D		75.13 ± 0.84^a,b,d	74.00 ± 0.44^h,l	140.13 ± 0.75^p,q,r,s
E		79.50 ± 0.70^a,e	68.83 ± 0.06^h,i,m	79.03 ± 1.78^s,t
F		85.47 ± 0.76^c,d,f	84.40 ± 0.85^j,l,m,n	88.80 ± 0.44^q,r,s,u
Resveratrol		69.47 ± 3.44^a,b,c,e,f,g	75.52 ± 4.99^h,n,o	87.10 ± 10.36^r,s,v
Kojic acid		84.00 ± 1.41^d,g	55.60 ± 0.56^h,i,j,l,m,n,o	5.30 ± 0.17^p,q,r,s,t,u,v

*Means followed by the same letters differ by ANOVA followed by Tukey post hoc test (^a–v𝑃<0.001).