A Thirty-Year Follow-Up Surveillance Study for Neoplasia of a Dutch Ulcerative Colitis Cohort

Table 2

Cox regression analysis per independent factor.

(a) Positive for any dysplasia

Factors	Number (%)	Univariate			Multivariate
		HR	95% CI	Sig.	HR	95% CI	Sig.
Sex		1,552	0.963–2.502	0.071	1,430	0.878–2.329	0.150
Male	45/148 (30.4)
Female	27/145 (18.6)
Location		1,922	1.115–3.312	0.019	1,918	1.111–3.311	0.019
Pancolitis	55/178 (30.9)
Distal colitis	17/115 (14.8)
Age at 1st surveillance, yrs		1,032	1.013–1.051	0.001	1,028	1.009–1.047	0.004

(b) Positive for HGD/CRC

Factors	Number (%)	Univariate			Multivariate
		HR	95% CI	Sig.	HR	95% CI	Sig.
Sex		1,354	0.586–3.129	0.479	1,460	0.624–3.421	0.383
Male	14/148 (9.5)
Female	9/145 (6.2)
Location		13,232	1.783–98.182	0.012	13,508	1.818–100.384	0.011
Pancolitis	22/178 (12.4)
Distal colitis	1/115 (0.9)
Age at 1st; surveillance, yrs		1,008	0.975–1.042	0.654	1,002	0.968–1.036	0.926

(c) Positive for CRC

Factors	Number (%)	Univariate			Multivariate
		HR	95% CI	Sig.	HR	95% CI	Sig.
Sex		0.748	0.271–2.064	0.575	0.874	0.310–2.460	0.798
Male	7/148 (4.7)
Female	8/145 (5.5)
Location		8,305	1.092–63.165	0.041	8,402	1.102–64.062	0.040
Pancolitis	14/178 (7.9)
Distal colitis	1/115 (0.9)
Age at 1st; surveillance, yrs		0.986	0.943–1.031	0.531	0.984	0.941–1.029	0.486