The Effect of Reagents Mimicking Oxidative Stress on Fibrinogen Function

Table 1

Fibers thickness and average number of fibrin fibers per 1 μm² of fibrin clot.

	MDA		NaOCl		SIN-1
	Control fibrinogen	Modified fibrinogen	Control fibrinogen	Modified fibrinogen	Control fibrinogen	Modified fibrinogen
Fibers thickness (nm)	115.2 ± 30.8	102.0 ± 21.8	136.7 ± 48.8	107.4 ± 23.7	130.3 ± 43.0	102.1 ± 34.0
Average no. of fibers strands per field (1 𝜇m^2)	12.9 ± 1.0	20.5 ± 3.3	13.1 ± 1.8	2.0 ± 1.2	14.1 ± 1.1	20.4 ± 2.2

Quantity and thickness of fibrin fibers were obtained from three experiments. Thickness of fibers is presented as mean of 45 values (15 values per experiment) with SD. Count of fibers was acquired as mean value from 6 areas (2 areas per experiment). Differences between control and modified fibrinogen were significant in both thickness and quantity parameters (paired Student’s 𝑡-test) with probability 𝑃<0.05.