Extraction Optimization of Tinospora cordifolia and Assessment of the Anticancer Activity of Its Alkaloid Palmatine

Table 5

Inhibition of dimethylbenz(a)anthracene (DMBA)/croton oil induced skin carcinogenesis in Swiss albino mice by palmatine treatment.

Treatment	GSH 𝜇mole/mg protein	SOD 𝜇mole/mg protein	Catalase U/mg protein	LPO nmole/mg protein
Group 1	24.28±1.60^∗	74.42±2.06^∗	36.60±1.72^∗	1.82±0.86^∗
Group 2	11.02±0.96	59.59±2.15	8.97±1.07	4.82±1.71
Group 3	26.68±1.20^∗	73.10±1.56^∗	37.50±2.40^∗	2.10±0.76^∗
Group 4	28.05±2.83^∗	77.50±0.84^∗	38.84±3.18^∗	2.29±0.80^∗
Group 5	32.09±0.90^∗	84.05±3.78^∗	41.61±3.61^∗	1.94±0.49^∗

Values with * superscripts were significant (𝑃<0.05) in comparison with Group 2.