Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma
Table 1
Correlation between miR-183 expression and clinicopathological factors of HCC.
Factors
miR-183 level 2−ΔΔCTM (P25~P75)
Gender
Male
79
9.178 (2.564~29.231)
−0.023
0.827
Female
13
6.431 (3.886~16.491)
Age (years)
≤55
50
8.415 (2.715~31.069)
−0.002
0.981
>55
42
10.543 (2.583~23.855)
HBV
+
72
8.880 (2.687~21.728)
−0.078
0.887
−
20
10.2773 (2.646~47.116)
HCV
+
6
12.556 (0.830~99.732)
−0.002
0.985
−
86
9.015 (2.715~23.855)
Liver cirrhosis
Yes
86
9.845 (2.761~29.437)
0.235
0.025
No
6
3.007 (1.606~4.862)
Child-Pugh score
A
77
8.583 (2.615~29.643)
0.046
0.661
B
15
10.920 (4.737~19.942)
AFP (ng/mL)
≤400
52
10.525 (2.588~26.252)
−0.040
0.705
>400
40
8.026 (2.799~28.121)
Tumor number
1
59
7.803 (2.961~33.794)
0.064
0.544
≥2
33
10.235 (3.989~24.257)
Tumor size (cm)
≤3
12
8.717 (2.799~29.403)
0.027
0.799
>3
80
10.547 (2.223~22.574)
Vein invasion
Yes
25
9.178 (4.228~19.525)
0.014
0.892
No
67
8.583 (1.564~33.794)
TNM grade
I-II
46
5.480 (2.381~11.794)
0.213
0.042
III-IV
46
11.795 (4.231~33.874)
Tumor grade
W
22
4.754 (1.656~68.768)
−0.060
0.365
M
48
10.047 (3.010~28.786)
P
22
7.229 (2.190~11.677)
The Spearman correlation coefficients were used to analyze the correlation between miR-183 expression and clinicopathological factors; was considered statistically significant; W: well differentiated; M: moderately differentiated; P: poorly differentiated; HBV: hepatitis B virus; HCV: hepatitis C virus; : correlation coefficient; TNM: tumor node metastasis; AFP: alpha-fetoprotein.