Research Article

Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma

Table 1

Correlation between miR-183 expression and clinicopathological factors of HCC.

Factors miR-183 level 2−ΔΔCT   M (P25~P75)

Gender
 Male799.178 (2.564~29.231)−0.0230.827
 Female136.431 (3.886~16.491)
Age (years)
 ≤55508.415 (2.715~31.069)−0.0020.981
 >554210.543 (2.583~23.855)
HBV
 +728.880 (2.687~21.728)−0.0780.887
 −2010.2773 (2.646~47.116)
HCV
 +612.556 (0.830~99.732)−0.0020.985
 −869.015 (2.715~23.855)
Liver cirrhosis
 Yes869.845 (2.761~29.437)0.2350.025
 No63.007 (1.606~4.862)
Child-Pugh score
 A778.583 (2.615~29.643)0.0460.661
 B1510.920 (4.737~19.942)
AFP (ng/mL)
 ≤4005210.525 (2.588~26.252)−0.0400.705
 >400408.026 (2.799~28.121)
Tumor number
 1597.803 (2.961~33.794)0.0640.544
 ≥23310.235 (3.989~24.257)
Tumor size (cm)
 ≤3128.717 (2.799~29.403)0.0270.799
 >38010.547 (2.223~22.574)
Vein invasion
 Yes259.178 (4.228~19.525)0.0140.892
 No678.583 (1.564~33.794)
TNM grade
 I-II465.480 (2.381~11.794)0.2130.042
 III-IV4611.795 (4.231~33.874)
Tumor grade
 W224.754 (1.656~68.768)−0.0600.365
 M4810.047 (3.010~28.786)
 P227.229 (2.190~11.677)

The Spearman correlation coefficients were used to analyze the correlation between miR-183 expression and clinicopathological factors; was considered statistically significant; W: well differentiated; M: moderately differentiated; P: poorly differentiated; HBV: hepatitis B virus; HCV: hepatitis C virus; : correlation coefficient; TNM: tumor node metastasis; AFP: alpha-fetoprotein.