Research Article
Expression and Significance of MicroRNA-183 in Hepatocellular Carcinoma
Table 2
Univariate and multivariate analyses of prognosis factors associated with overall and disease-free survival rates in patients with HCC.
| | Factors | Overall survival | Disease-free survival | | Univariate |
Multivariate | Univariate |
Multivariate | | HR (95% CI) | P | HR (95% CI) | |
| | Gender (male/female) | NS | — | NA | NS | — | NA | | Age (≤55/>55) | NS | — | NA | NS | — | NA | | HCV (+/−) | NS | — | NA | NS | — | NA | | HBV (+/−) | NS | — | NA | NS | — | NA | | Liver cirrhosis (yes/no) | NS | — | NA | NS | — | NA | | Child-Pugh score (A/B) | NS | — | NA | NS | — | NA | | Tumor size (≤3/>3 cm) | NS | — | NA | NS | — | NA | | Tumor number (1/≥2) | NS | — | NA | 0.001 | 1.211 (1.182–3.128) | 0.006 | | Growth pattern (expansive/invasive) | 0.000 | 3.006 (1.360–6.646) | 0.007 | 0.001 | — | NS | | Tumor grade (W/M/P) | NS | — | NA | NS | — | NA | | TNM grade (I-II/III-IV) | 0.011 | — | NS | 0.006 | | NS | | AFP level (≤20/>20 ng/mL) | NS | — | NA | NS | — | NA | | Vein invasion (yes/no) | 0.000 | 1.860 (0.929–3.724) | 0.008 | 0.001 | 2.043 (1.061–3.934) | 0.033 | | miR-183 (high/low group) | NS | — | NA | NS | — | NA |
|
|
was considered statistically significant; W: differentiated; M: moderately differentiated; P: poor differentiated; HBV: hepatitis B virus; HCV: hepatitis C virus; : correlation coefficient; TNM: Tumor Node Metastasis; AFP: alpha-fetoprotein; HR: Hazard ratio; 95% CI: 95% confidence interval.
|
