Absorption and Metabolism Characteristics of Rutin in Caco-2 Cells

Figure 3

Absorption of rutin in Caco-2 Cells. (a) Time-dependent intracellular accumulation of rutin and its metabolites at 37°C from 10 min to 6 h. (b) Dose-dependent absorption of rutin and its metabolites at 37°C from 5 to 200 μM. (c) Intracellular accumulation of rutin and its metabolites after incubation with 100 μM rutin for 2 h. (d) Intracellular accumulation of rutin in the presence of different inhibitors (10 μM verapamil, 20 μM cyclosporine, 20 μM MK 571, respectively). Each value is the mean ± the SD of seven determinations. Statistical significance: **𝑃<0.01; *𝑃<0.05.

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