A Ternary Catalytic System for the Room Temperature Suzuki-Miyaura Reaction in Water

Table 4

Suzuki reactions between different aryl halides and phenylboronic acid using the ternary system (LDH-Pd-CD) at room temperature during 8 hours with 1 : 20 ratio of Pd : HP-β-CD.

Entry	Aryl halide	Product	Yield (%)
1	4-Bromoacetophenone	4-Phenylacetophenone	98^a
2	Iodobenzene	Biphenyl	97^a
3	4-Iodonitrobenzene	4-Nitrobiphenyl	98^a
4	4-Iodotoluene	4-Methylbiphenyl	96^a
5	Bromobenzene	Biphenyl	93^b
6	Chlorobenzene	Biphenyl	13^b,c
7	4-Chloronitrobenzene	4-Nitrobiphenyl	16^b,c

^aIsolated yield. ^bMeasured by GC-MS. ^c24 hours under reflux.