The Durie-Salmon and International Staging systems criteria.
Stage
Durie-Salmon criteria
International Staging system criteria
I
All of the following: hemoglobin value > 10 g/dL, serum calcium value normal or ≤3 mmol/L bone X-ray, normal bone structure (scale 0), or solitary bone plasmacytoma only Low M-component production rate (IgG value < 5 g/dL; IgA value < 3 g/dL; Bence-Jones protein < 4 g/24 h)
Beta-2 microglobulin < 3.5 mmol/L and albumin ≥ 3.5 g/dL
II
Neither stage I nor stage III
Neither stage I nor stage III
III
One or more of the following: hemoglobin value < 8.5 g/dL serum calcium value > 3 mmol/L, advanced lytic bone lesions (scale 3) High M-component production rate (IgG value > 7 g/dL; IgA value > 5 g/dL; Bence-Jones protein > 12 g/24 h)
Beta-2 microglobulin > 5.5 mmol/L
Durie-Salmon subclassifications: relatively normal renal function (serum creatinine level < 177 mmol/L [<2 mg/dL]). Abnormal renal function (serum creatinine level ≥ 177 mmol/L [≥2 mg/dL]).
