1.5–1.9 times baseline OR ≥0.3 mg/dL (≥26.5 mmol/L) increase
<0.5 mL/kg/h for 6–12 h
2
2.0–2.9 times baseline
<0.5 mL/kg/h for ≥12 h
3
3.0 times baseline OR Increase in serum creatinine to ≥4.0 mg/dL (≥353.6 mmol/L) OR Initiation of renal replacement therapy OR, in patients <18 years, decrease in eGFR to <35 ml/min per 1.73 m2