Multiple Myeloma and Kidney Disease

Table 5

Classification of CKD based on presence or absence of systemic disease and location within the kidney of pathologic-anatomic findings [33].

	Examples of systemic diseases affecting the kidney	Examples of primary kidney diseases
Glomerular diseases	Diabetes, systemic autoimmune diseases, systemic infections, drugs, and neoplasia (including amyloidosis)	Diffuse, focal, or crescentic proliferative GN, focal and segmental glomerulosclerosis, membranous nephropathy, and minimal change disease
Tubulointerstitial diseases	Systemic infections, autoimmune, sarcoidosis, drugs, urate, and environmental toxins,; Multiple myeloma	Urinary-tract infections, stones, and obstruction
Vascular diseases	Atherosclerosis, hypertension, ischemia, cholesterol emboli, systemic vasculitis, thrombotic microangiopathy, and systemic sclerosis	ANCA-associated renal limited vasculitis and fibromuscular dysplasia
Cystic and congenital diseases	Polycystic kidney disease, Alport syndrome, and Fabry disease	Renal dysplasia, medullary cystic disease, and podocytopathies