Research Article

Nexfin Noninvasive Continuous Hemodynamic Monitoring: Validation against Continuous Pulse Contour and Intermittent Transpulmonary Thermodilution Derived Cardiac Output in Critically Ill Patients

Table 3

Comparison of TDCO versus NexCO including subgroup analysis for patients with low MAP, low and high TDCO, low and high SVRI, and high dose norepinephrine and hypothermia.

OverallLow MAPLow TDCOHigh TDCOLow SVRIHigh SVRINorepinephrineHypothermia
≤70 mmHg≤4 L/min≥8 L/min≤1700 dyne·s·cm−5/m²≥3000 dyne·s·cm−5/m²≥0,3 µg/kg/min≤35°C

No. of patients45199182961122
No. of paired measurements13527163258142763

Mean TDCOL/min6.66.23.88.27.24.56.76.5

0.670.820.010.670.740.810.890.70
P value<0.001<0.001NS<0.001<0.001<0.001<0.001<0.001

BiasL/min0.40.9 0.90.6 0.40.1
PrecisionL/min1.21.11.51.11.31.311.3
Lower LAL/min
Upper LAL/min2.732.533.22.42.32.6

Percentage error%3634782637572939

TDCO: thermodilution cardiac output.
: Pearson correlation coefficient.
LA: limits of agreement.
MAP: mean arterial pressure.
SVRI: systemic vascular resistance index.