Association between TLR4 and TLR9 Gene Polymorphisms with Development of Pulmonary Tuberculosis in Zahedan, Southeastern Iran

Table 3

TLR4 SNPs allele and genotype frequencies in patients and controls.

TLR4 polymorphism	PTB patients (𝑛 = %)	Controls (𝑛 = %)	𝜒^2	𝑃 value*	OR (95% CI)
Asp299Gly (A896G)
AA	122 (98.4)	146 (98)
AG	2 (1.6)	3 (2)	0.06	0.6	0.8 (0.13–4.9)
GG	0	0
Total	124	149
A (WT)	246 (99.2)	295 (99)
G (Mut)	2 (0.8)	3 (1)	0.06	0.6	1.3 (0.2–7.6)
Thr399Ile (C1196T)
CC	112 (90.3)	141 (94.6)
TC	10 (8.1)	7 (4.7)	1.4	0.18	1.8 (0.7–4.9)
TT	2 (1.6)	1 (0.7)	0.6	0.4	2.5 (0.2–2.8)
Total	124	149
C (WT)	234 (94.4)	289 (97)
T (Mut)	14 (5.6)	9 (3)	2.3	0.1	1.9 (0.8–4.5)

*Compared with healthy controls. A corrected 𝑃 value < 0.05 was considered significant.