Association of Interleukin-6 Gene Promoter Polymorphism with Coronary Artery Disease in Pakistani Families

Table 1

Baseline and clinical characteristics of study population 𝑛=88.

Parameters	Patients (𝑛=36)	Control (𝑛=52)	𝑃 value
Age (years)	46.4±18.7	35.2±17.4	0.0050^a
BMI (kg/m^2)	25.9±3.5	25.2±3.5	0.2755^a
Female/male (𝑛)	16 (44.4%)/20 (55.6%)	22 (42.3%)/30 (57.7%)	0.8423^b
Smokers/nonsmokers (𝑛)	8 (22.2%)/28 (77.8%)	5 (9.6%)/47 (90.4%)	0.1825^b
SES (low/high) (𝑛)	23 (63.9%)/13 (36.1%)	31 (60%)/21 (40%)	0.8555^b
Activity (low/high) (𝑛)	21 (58.3%)/15 (41.7%)	9 (17.3%)/43 (82.7%)	0.0002^b
Stressed/nonstressed (𝑛)	27 (75%)/9 (25%)	16 (30.8%)/36 (69.2%)	0.0001^b
Hypertensive/nonhypertensive (𝑛)	22 (61.1%)/14 (38.9%)	7 (13.5%)/45 (86.5%)	<0.0001^b
Systolic blood pressure (𝑛)	147.5±25.6	126.7±14.6	<0.0001^a
Diastolic blood pressure (𝑛)	92.9±12.5	82.8±7.7	<0.0001^a
Total-cholesterol (mg/dL)	198.2±40.7	170.7±28.4	0.0035^a
Triglycerides (mg/dL)	134.4±46.6	111.5±26.4	0.0257^a
LDL-cholesterol (mg/dL)	114.3±30	97.5±11.8	0.0295^a
HDL-cholesterol (mg/dL)	38.0±8.5	43.6±8.1	0.0012^a
Serum IL-6 (ng/dL)	3.9±1.7	3.0±0.7	0.0268^a
Serum hsCRP (mg/L)	9.4±5.7	3.0±2.8	<0.0001

Values are given as means ± SD.
^a𝑃 values were calculated by using the Mann-Whitney test.
^b𝑃 values were calculated by the Pearson chi-square test.