Goblet Cell Carcinoids of the Appendix : Table 1

Table 1: Suggested algorithm for the treatment and followup from the literature cited in the paper.


	Histology:
	(i) Scattered staining for chromogranin A and synaptophysin, along with mucus.
	(ii) Ki67 index.
	(iii) Staging according to Tang et al. [12].
	Imaging:
Diagnostic procedures	(i) CT/MRI of the chest and the abdomen/pelvis
	(ii) MRI of the abdomen/pelvis
	(iii) Somatostatin receptor scintigraphy, Ga⁶⁸-PET scans are usually negative
	(iv) FDG-PET and MIBG-PET scannings are usually negative
	Biochemistry:
	(i) CEA, CA-19-9, CA-125
	(ii) Chromogranin A and U-5HIAA usually normal

	Appendectomy
Surgical therapy	Hemicolectomy (standard surgical treatment)
	Debulking surgery when possible

Medical therapy	5-fluorouracil-based chemotherapeutic regimen
Medical therapy	Cytoreductive surgery combined with HIPEC in selected cases

	(i) Clinical: abdominal pain, weight loss
Followup	(ii) Biochemistry: CEA, CA-19-9, and CA-125
	(iii) Imaging: CT or MRI every 3–6 months, then yearly, mimicking the guidelines for colorectal adenocarcinoma. Lifelong followup.