Review Article
Goblet Cell Carcinoids of the Appendix
Table 1
Suggested algorithm for the treatment and followup from the literature cited in the paper.
| | Histology: | | (i) Scattered staining for chromogranin A and synaptophysin, along with mucus. | | (ii) Ki67 index. | | (iii) Staging according to Tang et al. [12]. | | Imaging: | Diagnostic procedures | (i) CT/MRI of the chest and the abdomen/pelvis | | (ii) MRI of the abdomen/pelvis | | (iii) Somatostatin receptor scintigraphy, Ga68-PET scans are usually negative | | (iv) FDG-PET and MIBG-PET scannings are usually negative | | Biochemistry: | | (i) CEA, CA-19-9, CA-125 | | (ii) Chromogranin A and U-5HIAA usually normal |
| | Appendectomy | Surgical therapy | Hemicolectomy (standard surgical treatment) | | Debulking surgery when possible |
| Medical therapy | 5-fluorouracil-based chemotherapeutic regimen | Cytoreductive surgery combined with HIPEC in selected cases |
| | (i) Clinical: abdominal pain, weight loss | Followup | (ii) Biochemistry: CEA, CA-19-9, and CA-125 | | (iii) Imaging: CT or MRI every 3–6 months, then yearly, mimicking the guidelines for colorectal adenocarcinoma. Lifelong followup. |
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