The Value of Routine Polymerase Chain Reaction Analysis of Intraocular Fluid Specimens in the Diagnosis of Infectious Posterior Uveitis

Table 7

Comparison of estimated sensitivity, specificity, positive predictive value, and negative predictive value for specimen sites.

	Sample number	True +ve		False +ve		True −ve		False −ve		Sens	Spec	PPV	NPV
AC	153	16	10%	0	0%	129	84%	8	5%	67%	100%	100%	94%
V	332	81	24%	3	1%	237	71%	11	3%	88%	99%	96%	96%
NS	10	2	20%	0	0%	8	80%	0	0%	—	—	—	—
Total	495	97	20%	3	1%	373	75%	19	4%	84%	99%	97%	95%

AC: anterior chamber; V: vitreous; NS: not specified; Sens: sensitivity; Spec: specificity; PPV: positive predictive value; NPV: negative predictive value.
(1) Three patients had samples taken from an unknown site (not specified in the clinical notes).
(2) Simultaneous vitreous and aqueous sampling was performed on 4 patients.
(3) Two patients had repeat sampling (both were vitreous sample repeats).