Naturally Occurring Hepatitis B Virus B-Cell and T-Cell Epitope Mutants in Hepatitis B Vaccinated Children

Table 1

Serologic status and serum HBV DNA in HBsAg positive vaccinated children.

Subject	Age (years)	Sex^a	Serologic marker		Genotype/serotype^c	Viral load^d
			Anti-HBs^b	Anti-HBc
Y1	5.0	F	−	+	Ba/adw	7.0 × 10^6
Y2	4.3	F	−	+	Ba/adw	8.5 × 10^5
Y3	6.5	M	−	−	Ba/adw	5.89 × 10^5
Y4	7.0	F	−	+	Ba/adw	1.49 × 10^6
Y5	6.7	M	−	+	C/adr	3.23 × 10^6

aF: female; M: male.
^bThe value below the detection limit (2.0 IU/L) was considered negative for anti-HBs.
^cGenotype and serotype were derived from sequence alignment and phylogenetic analysis.
^dCopies/mL.