Naturally Occurring Hepatitis B Virus B-Cell and T-Cell Epitope Mutants in Hepatitis B Vaccinated Children

Table 2

Nucleotide changes in the S and pre-S regions.

Subject	S (nt 284–774)	Pre-S (nt 2848–154)
Y1	A482C, T586C, A748G	T2910C, A2989C, T3026C, G3075A, C3100T, C3174T, G35A, T109A
Y2	T586C, A748G, T753A	T2882C, A2891G, A2906G, T2910C, C2985T, A2989C, C3050T, C3091T, A3092C, C3097A, C3174T, G35A, C46A, T147C
Y3	T586C, A748G, T753A	T2910C, C2985T, A2989C, C3050T, C3091T, A3092C, C3097A, C3174T, G35A, C46A, G97A, T147C
Y4	G316A, G372T, T586C, A748G, T753A	T2910C, C2985T, A2989C, C3050T, C3091T, A3092C, C3097A, C3174T, G35A, C46A, T147C
Y5	T312C, T367C, C400A, A783G	C2875A, G2927A, A2946G, T2958C, G3000C, C3008A, C3013A, T3031G, C3033A, T3051C, A3064G, T3066A, A3111G, C3116T, G3120A, A3186G, G6C, C7A, T31C, C52T, T109A, T150C, T154C

GenBank no. D00330 (genotype Ba/serotype adw) was used as the reference sequence for Y1–Y4. GenBank number AF223958 (genotype C/serotype adr) was used as the reference sequence for Y5.