Research Article

Naturally Occurring Hepatitis B Virus B-Cell and T-Cell Epitope Mutants in Hepatitis B Vaccinated Children

Table 3

Amino acid variations in the S region compared with the reference sequence of A2-derived HBV vaccine.

SubjectB-cell epitopeT-cell epitopeRegion outside the B- and T-cell epitopes
aa 44–49aa 122–148
“a” determinant
aa 160–207aa 28–51aa 136–155

Y1S45TN131TI194V, S207NL42S, S45TWild typeP56Q, T57I, N59S, S64C, F85C, I110L, T114S
Y2S45TN131TI194V, Y200F, S207NS45TWild typeP56Q, T57I, N59S, S64C, F85C, T114S
Y3S45TN131TI194V, S207NL42A, S45TWild typeP56Q, T57I, N59S, S64C, F85C, T114S
Y4S45TN131TI194V, S207NL42I, S45TWild typeP56Q, T57I, N59S, S64C, R73L, F85C, T114S
Y5S45A, V47T, L49PT126I, N131T, T143S, G145AK160R, Y161F, I194V, S207NL42S, G43R, S45A, V47T, L49PT143S, G145AI110L, S113T, T114S

GenBank number Z35717 (genotype A2/serotype adw) was used as the reference sequence of A2-derived HBV vaccines.