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| GeneticsA | |
|
| AD-causative genes | |
| Presenilin 1 (PSEN1) | |
| Presenilin 2 (PSEN2) | |
| Aβ A4 precursor protein (APP) | |
| AD-susceptible genes | |
| Apolipoprotein E epsilon 4 (APOEε4) | |
| Sortilin-related receptor 1 (SORL1) | |
| Amyloid beta A4 precursor protein-binding, family B, member 2 (APBB2) | |
| Hemochromatosis (HFE) | |
| Nitric oxide synthase 3 (NOS3) | |
| PAX-interacting protein 1 (PAXIP1) | |
| Urokinase-type plasminogen activator (PLAU) | |
| Alpha-2 macroglobulin (A2M) | |
| Bleomycin hydrolase (BLMH) | |
| Myeloperoxidase (MPO) | |
| Angiotensin-converting enzyme (ACE) | |
| New AD Susceptible Loci | |
| Programmed cell death protein 4 (PDCD4) | |
| Evolutionarily conserved signaling intermediate in Toll (ECSIT) | |
| Phosphatidylinositol binding clathrin assembly protein (PICALM) | |
| Complement receptor type 1 (CR1) | |
| Myc box-dependent-interacting protein 1 (BIN1) | |
| CD2-associated protein (CD2AP) | |
| CD33 | |
| Ephrin type-A receptor 1 (EPHA1) | |
| Clusterin (CLU) | |
| ATP-binding cassette subfamily A member 7 (ABCA7) | |
| Membrane-spanning 4A4E and 6A (MS4A6A/MS4A4E) | |
| Oxidized low-density lipoprotein (LDL) receptor (OLR1) | |
| Cholesterol 24-hydroxylase (CYP46) | |
|
| Environmental exposuresB | |
|
| Health factors | |
| Food diets | |
| Cigarette smoking | |
| Alcohol consumption | |
| Head trauma | |
| Viral infections | |
| Systemic inflammation | |
| Metal and pesticide exposure | |
| Psychosocial factors | |
| Education | |
| Social network | |
| Leisure activities | |
| Physical activity | |
| Chronic stress | |
| Depression | |
| Somatic Factors | |
| Blood pressure | |
| Obesity | |
| Diabetes mellitus | |
| Cardiovascular diseases | |
| Cerebrovascular diseases | |
| Hyperlipidemia | |
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