DNA Damage Sensor γ-H2AX Is Increased in Preneoplastic Lesions of Hepatocellular Carcinoma
Figure 2
γ-H2AX is significantly increased in preneoplastic lesions in the liver. (a) Representative images of immunostaining for γ-H2AX in non-HCC tissues. CH: chronic hepatitis; LC: liver cirrhosis; DN: dysplastic nodule (original magnification ×40). (b) Dot plots showing the γ-H2AX labeling index in normal livers (), chronic hepatitis (CH; ), liver cirrhosis (LC; ), dysplastic nodule (DN; ), and HCC (). Horizontal bars depict the mean value, and vertical bars indicate the standard deviation. : value of <0.01 versus normal livers; : value of <0.01 versus dysplastic nodule.