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The Scientific World Journal
Volume 2013 (2013), Article ID 597095, 7 pages
DNA Damage Sensor γ-H2AX Is Increased in Preneoplastic Lesions of Hepatocellular Carcinoma
1Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2-746 Asahimachi-dori, Niigata 951-8518, Japan
2Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 2-746 Asahimachi-dori, Niigata 951-8518, Japan
3Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, 2-746 Asahimachi-dori, Niigata 951-8518, Japan
4Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 2-746 Asahimachi-dori, Niigata 951-8518, Japan
Received 6 December 2012; Accepted 5 February 2013
Academic Editors: M. Ladekarl, P.-D. Line, and P. Stål
Copyright © 2013 Yasunobu Matsuda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. M. Llovet, S. Ricci, V. Mazzaferro, et al., “Sorafenib in advanced hepatocellular carcinoma,” The New England Journal of Medicine, vol. 359, pp. 378–390, 2008.
- P. A. Farazi and R. A. DePinho, “Hepatocellular carcinoma pathogenesis: from genes to environment,” Nature Reviews Cancer, vol. 6, no. 9, pp. 674–687, 2006.
- N. Ince and J. R. Wands, “The increasing incidence of hepatocellular carcinoma,” The New England Journal of Medicine, vol. 340, no. 10, pp. 798–799, 1999.
- Y. Matsuda, T. Ichida, and M. Fukumoto, “Hepatocellular carcinoma and liver transplantation: clinical perspective on molecular targeted strategies,” Medical Molecular Morphology, vol. 44, pp. 117–124, 2011.
- C. Della Corte and M. Colombo, “Surveillance for hepatocellular carcinoma,” Seminars in Oncology, vol. 39, pp. 384–398, 2012.
- I. J. Groisman, R. Koshy, F. Henkler, J. D. Groopman, and M. A. Alaoui-Jamali, “Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells,” Carcinogenesis, vol. 20, no. 3, pp. 479–483, 1999.
- F. Zhao, N. B. Hou, X. L. Yang et al., “Ataxia telangiectasia-mutated-Rad3-related DNA damage checkpoint signaling pathway triggered by hepatitis B virus infection,” World Journal of Gastroenterology, vol. 14, no. 40, pp. 6163–6170, 2008.
- C. M. Kim, K. Koike, I. Saito, T. Miyamura, and G. Jay, “HBx gene of hepatitis B virus induces liver cancer in transgenic mice,” Nature, vol. 351, no. 6324, pp. 317–320, 1991.
- Y. Matsuda and T. Ichida, “Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis,” Medical Molecular Morphology, vol. 42, no. 3, pp. 138–142, 2009.
- W. H. Wang, R. L. Hullinger, and O. M. Andrisani, “Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis,” Journal of Biological Chemistry, vol. 283, no. 37, pp. 25455–25467, 2008.
- S. Prost, J. M. Ford, C. Taylor, J. Doig, and D. J. Harrison, “Hepatitis B x protein inhibits p53-dependent DNA repair in primary mouse hepatocytes,” Journal of Biological Chemistry, vol. 273, no. 50, pp. 33327–33332, 1998.
- L. Jia, X. W. Wang, and C. C. Harris, “Hepatitis B virus x protein inhibits nucleotide excision repair,” International Journal of Cancer, vol. 80, no. 6, pp. 875–879, 1999.
- C. K. Lai, K. S. Jeng, K. Machida, Y. S. Cheng, and M. M. C. Lai, “Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation,” Virology, vol. 370, no. 2, pp. 295–309, 2008.
- K. Machida, G. Mcnamara, K. T. H. Cheng et al., “Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes,” Journal of Immunology, vol. 185, no. 11, pp. 6985–6998, 2010.
- K. Matsumoto, Y. Satoh, H. Sugo et al., “Immunohistochemical study of the relationship between 8-hydroxy-2′-deoxyguanosine levels in noncancerous region and postoperative recurrence of hepatocellular carcinoma in remnant liver,” Hepatology Research, vol. 25, no. 4, pp. 435–441, 2003.
- H. Tanaka, N. Fujita, R. Sugimoto et al., “Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C,” British Journal of Cancer, vol. 98, no. 3, pp. 580–586, 2008.
- L. J. Kuo and L. X. Yang, “γ-H2AX- a novel biomaker for DNA double-strand breaks,” In Vivo, vol. 22, no. 3, pp. 305–310, 2008.
- N. F. Lowndes and G. W. L. Toh, “DNA repair: the importance of phosphorylating histone H2AX,” Current Biology, vol. 15, no. 3, pp. R99–R102, 2005.
- Liver Cancer Study Group of Japan, General Rules for the Clinical and Pathological Study of Primary Liver Cancer, Kanehara, Tokyo, Japan, 5th edition, 2008.
- C. Bertram and R. Hass, “Cellular responses to reactive oxygen species-induced DNA damage and aging,” Biological Chemistry, vol. 389, no. 3, pp. 211–220, 2008.
- A. Poehlmann and A. Roessner, “Importance of DNA damage checkpoints in the pathogenesis of human cancers,” Pathology Research and Practice, vol. 206, no. 9, pp. 591–601, 2010.
- J. Kobayashi, “Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to γ-H2AX through FHA/BRCT domain,” Journal of Radiation Research, vol. 45, no. 4, pp. 473–478, 2004.
- D. Klokov, S. M. MacPhail, J. P. Banáth, J. P. Byrne, and P. L. Olive, “Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays,” Radiotherapy and Oncology, vol. 80, no. 2, pp. 223–229, 2006.
- J. Bartkova, Z. Hořejší, K. Koed et al., “DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis,” Nature, vol. 434, no. 7035, pp. 864–870, 2005.
- V. G. Gorgoulis, L. V. F. Vassiliou, P. Karakaidos et al., “Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions,” Nature, vol. 434, no. 7035, pp. 907–913, 2005.
- H. Kim, B. K. Oh, M. Roncalli et al., “Large liver cell change in hepatitis B virus-related liver cirrhosis,” Hepatology, vol. 50, no. 3, pp. 752–762, 2009.