Genetic Markers Associated to Dyslipidemia in HIV-Infected Individuals on HAART

Table 3

Mean metabolic variables according to polymorphisms analyzed.

Polymorphisms	Total cholesterol; (mg/dL)		LDL-C; (mg/dL)		HDL-C; (mg/dL)		Triglycerides; (mg/dL)
	𝑁	M ± SD	𝑁	M ± SD	𝑁	M ± SD	𝑁	M ± SD
APOA5 −1131T>C (rs662799)
T/T	499	191±80	458	106±72	498	48±88	499	187±157
T/C + C/C	92	196±78	83	107±12	92	45±16	92	243±230
P value		0.549		0.953		0.047^$		0.003^*£
P value corrected**		1.000		1.000		0.376		0.024
APOA5 S19W (56C>G; rs3135506)
C/C	486	192±49	443	106±37	485	48±15	486	199±177
C/G + G/G	106	197±43	99	112±35	107	50±17	107	183±144
P value		0.330		0.047^#		0.130		0.398*
P value corrected**		1.000		0.376		1.000		1.000
APOB SP Ins/Del (rs17240441)
Ins/ins	192	189±42^a	176	99±31^c	192	52±15	193	195±167
Ins/del	175	193±51^ab	158	106±36^cd	175	50±14	176	195±193
Del/del	39	210±45^b	37	120±41^d	39	54±13	39	187±103
P value		0.036^§		0.006^§		0.245		0.996*
P value corrected**		0.288		0.048		1.000		1.000
APOB XbaI, 7673C>T (rs693)
C/C	122	183±42^e	112	95±35^g	122	52±15	122	187±126
C/T	202	194±42^ef	185	107±31^h	201	50±14	203	193±163
T/T	81	203±59^f	73	110±41^ih	82	51±12	82	212±248
P value		0.007^§		0.002^§		0.705		0.791*
P value corrected**		0.056		0.016		1.000		1.000
APOC3 3238C>G (rs5128)
C/C	464	193 ± 48	424	107 ± 37	465	49 ± 16	440	191 ± 162
C/G + G/G	125	192 ± 49	115	108 ± 39	124	47 ± 15	124	210 ± 214
P value		0.718		0.833		0.295		0.905*
P value corrected**		1.000		1.000		1.000		1.000
APOE genotype
E2/E3	64	188±60	56	93±34^j	63	46±14	64	263±350^l
E3/E3	365	193±47	333	109±37^k	366	49±16	366	186±128^m
E3/E4	119	198±47	112	112±38^k	119	48±17	119	195±153^m
P value		0.209		0.002^¶		0.371		0.033^∗§
P value corrected**		0.836		0.008		1.000		0.132
LDLR intron 19G>T (rs6511720)
G/G	475	193±48	430	107±36	476	48±16	473	198±184
G/T + T/T	114	191±51	107	105±41	113	50±16	114	183±109
P value		0.612		0.427		0.120		0.971*
P value corrected**		1.000		1.000		1.000		1.000
SCAP 2386A>G (rs12487736)
A/A	164	195±49	146	107±39	164	50±17^n	164	201±162
A/G	287	194±48	263	107±35	287	49±15^no	287	197±197
G/G	137	188±47	129	107±41	137	45±14^o	138	188±124
P value		0.443		0.970		0.032^¥		0.971*
P value corrected**		1.000		1.000		0.128		1.000

HDL-C: high-density lipoprotein; LDL-C: low density lipoprotein.
* 𝑃 value expressed with tests performed with logn-transformed variable.
** 𝑃 value after Bonferroni correction for multiple testing.
§Adjusted for gender, age, and lipid-lowering agents use.
¶Adjusted for age, and lipid-lowering agents use.
^$Adjusted for gender, cigarette smoking, and PI use.
^£Adjusted for gender, age, lipid-lowering agents use, and PI.
^#Adjusted for gender, age, ethnic group, BMI, and lipid-lowering agents use.
^¥Adjusted for gender, cigarette smoking, ethnic group, and lipid-lowering agents use.
^abTukey test, Ins/Ins versus Ins/Del, 𝑃=0.619; Ins/Ins versus Del/Del, 𝑃=0.027; Ins/Del versus Del/Del, 𝑃=0.145.
^cdTukey test, Ins/Ins versus Ins/Del, 𝑃=0.231; Ins/Ins versus Del/Del, 𝑃=0.006; Ins/Del versus Del/Del, 𝑃=0.071.
^efTukey test, C/C versus C/T, 𝑃=0.053; C/C versus T/T, 𝑃=0.007; C/T versus T/T, 𝑃=0.598.
^ghiTukey test, C/C versus C/T, 𝑃=0.006; C/C versus T/T, 𝑃=0.008; C/T versus T/T, 𝑃=0.830.
^jkTukey test, E2/E3 versus E3/E3, 𝑃=0.011; E2/E3 versus E3/E4, 𝑃=0.005; E3/E3 versus E3/E4, 𝑃=0.628.
^lmTukey test, E2/E3 versus E3/E3, 𝑃=0.003; E2/E3 versus E3/E4, 𝑃=0.029; E3/E3 versus E3/E4, 𝑃=0.875.
^noTukey test, A/A versus A/G, 𝑃=0.594; A/A versus G/G, 𝑃=0.014; A/G versus G/G, 𝑃=0.071.