The Scientific World Journal

Research Article

Genome-Wide Analysis of DNA Methylation in Human Amnion

Table 2

List of top 15 differentially methylated autosomal genes in amnion tissues from term (TNL, TL) and preterm (PTL) deliveries ranked by statistical significance¹.


TNL versus TL²			TL versus PTL³
Gene	Locus	CpG island⁴	Gene	Locus	CpG island⁴

IL32	16p13.3	No	TOB1	17q21	No
EDARADD	1q42.3	No	PNPLA3	22q13.31	No
STK19	6p21.3	No	ZNF671	19q13.43	No
EXTL1	1p36.1	No	DAB2IP ⁷	9q33.1–q33.3	No
HLA-DQB2	6p21	No	MFNG	22q12	No
MFSD3	8q24.3	Yes	UCN	2p23–p21	Yes
RAB31	18p11.3	Yes	EXOC3L2	19q13.32	Yes
PNPLA3	22q13.31	No	SLC44A2	19p13.1	Yes
GRHPR	9q12	Yes	FBXL19-AS1 ⁶	16p11.2	Yes
MPHOSPH10	2p13.3	No	DLGAP5	14q22.3	Yes
PEG10 ⁵	7q21	No	SLC30A3	2p23.3	Yes
DSCR10 ⁶	21q22.13	No	CHFR	12q24.33	No
SRRD	22q12.1	Yes	C11orf1	11q23.1	No
POLI	18q21.1	Yes	SLC24A4	14q32.12	No
OSTalpha	3q29	No	PI4KB	1q21	No

¹Statistical significance was determined based on -values calculated from DiffScores. All genes listed here have a DiffScore >40 (corresponding to -value of <0.0001).
²Genes most highly methylated in the TL group compared to the TNL group.
³Genes most highly methylated in the PTL group compared to the TL group.
⁴Defined by the CpG island track in the UCSC Genome Browser.
⁵An imprinted gene.
⁶Non-protein coding genes.
⁷A gene identified as having three non-island CpG sites with a DiffScore >40.
Abbreviations: TNL: term no labor; TL: term labor; PTL: preterm labor.