New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities

Table 4

Antimicrobial activity of the titled urea and thiourea derivatives 8(a–j).

Compd.	Bacterial culture						Fungal culture
	S. aureus		P. aeruginosa		E. coli		A. flavus		A. niger		C. albicans
	ZOI^c	MIC	ZOI^a	MIC	ZOI^a	MIC	ZOI^a	MIC	ZOI^a	MIC	ZOI^a	MIC
4	14.9	60	13.4	65	12.7	50	10.9	65	10.5	65	11.3	45
8a	20.8	17	19.9	20	23.8	17	18.6	30	19.3	30	18.8	35
8b	16.3	40	19.2	30	17.3	45	13.8	80	13.7	80	16.3	40
8c	17.1	18	18.5	45	17.6	55	14.3	80	14.4	75	14.5	55
8d	19.8	20	20.5	20	24.7	15	19.9	20	19.6	30	19.8	20
8e	18.9	30	20.8	20	19.4	35	17.5	45	16.8	65	17.7	30
8f	20.1	15	19.8	25	20.5	30	19.2	20	20.1	20	19.3	25
8g	17.8	45	17.3	35	18.3	70	16.4	50	17.8	40	16.4	30
8h	16.1	40	16.2	35	15.2	70	13.9	80	14.5	70	13.8	80
8i	16.7	30	18.8	40	17.9	45	16.1	45	18.3	35	15.9	70
8j	19.7	25	20.8	20	22.8	20	19.0	25	19.6	25	19.7	20
Ciprofloxacin	22	04	23	05	27	04	—	—	—	—	—	—
Fluconazole	—	—	—	—	—	—	21	04	23	04	22	05

ZOI: zone of inhibition in mm.
^cConcentration of compounds at 200 µg/mL.