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RETRACTED
This article has been retracted as it is found to contain a substantial amount of material from a number of previously published papers. The three most plagiarized papers are: (1) K. I. Hidari and T. Suzuki, “Dengue virus receptor,” Tropical Medicine and Health, vol. 39, no. 4, supplement, pp. 37–43, 2011. (2) A. Cabrera-Hernandez and D. R. Smith, “Mammalian dengue virus receptors,” Dengue Bulletin, vol. 29, no. 662, pp. 119–135, 2005. (3) A. Cabrera-Hernandez, C.Thepparit, L. Suksanpaisan, and D. R. Smith, “Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70,” Journal of Medical Virology, vol. 79, no. 4, pp. 386–392, 2007.
The Scientific World Journal
Volume 2013 (2013), Article ID 684690, 6 pages
http://dx.doi.org/10.1155/2013/684690
Review Article

Recent Advances in DENV Receptors

Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

Received 27 February 2013; Accepted 3 April 2013

Academic Editors: G. Borkow and E. J. Im

Copyright © 2013 Shuyu Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dengue is an old disease caused by the mosquito-borne dengue viruses (DENVs), which have four antigenically distinct serotypes (DENV1–4). Infection by any of them can cause dengue fever (DF) and/or a more serious disease, that is, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). In recent decades, incidence of dengue disease has increased 30-fold, putting a third to half of the world’s population living in dengue-endemic areas at high infection risk. However, the pathogenesis of the disease is still poorly understood. The virus binding with its host cell is not only a first and critical step in their replication cycle but also a key factor for the pathogenicity. In recent years, there have been significant advances in understanding interactions of DENVs with their target cells such as dendritic cells (DC), macrophages, endothelial cells, and hepatocytes. Although DENVs reportedly attach to a variety of receptors on these cells, consensus DENV receptors have not been defined. In this review, we summarize receptors for DENVs on different cells identified in recent years.