A Comparative Genomic Study in Schizophrenic and in Bipolar Disorder Patients, Based on Microarray Expression Profiling Meta-Analysis
Figure 1
Volcano plots of DE probesets, generated from two-tailed Student’s t-test. Upregulated genes in the disease state are depicted with red-colored spots and downregulated genes with green-colored spots. The first three plots (a, b, c) represent DE genes in SZ patients from first, third, and fourth studies, respectively, and the following three plots (d, e, f) represent DE genes in BD patients from first, second, and fourth studies, respectively. FC ratio between gene expression in disease state and healthy state is depicted in the horizontal axes for each dataset in scale, and values in scale are depicted in vertical axes. All plots are similar in most studies, except for plot (e), which shows more green and red spots. This fact means that the number of DE genes is similar in most studies but in study 2 there is a greater number of statistically significant genes in comparison to other plots.
