Research Article

A Comparative Genomic Study in Schizophrenic and in Bipolar Disorder Patients, Based on Microarray Expression Profiling Meta-Analysis

Table 8

Genes present in DE gene lists from all studies including comparison of gene expression between SZ samples with control samples.

Gene symbolFC SZ versus controlFC SZ versus controlFC SZ versus controlGene title
(Study 1)(Study 3)(Study 4)

SRGN0.7770850.42152Serglycin
PRPF4B0.563723 PRP4 pre-mRNA processing factor 4
homolog B (yeast)
MT1X0.754667 Metallothionein 1X
GYG20.7545250.686934 Glycogenin 2
NR4A20.90769 0.550066 Nuclear receptor subfamily 4, group A, member 2
NPY0.568144 0.406243 Neuropeptide Y
SST0.83089 0.561683 Somatostatin
PALLD0.5097940.401231Paladin, cytoskeletal
Associated protein
AQP40.4493030.714565Aquaporin 4
ARPC1B0.3921730.597327 Actin-related protein 2/3 complex, subunit 1B, 41 kDa
PVALB0.403296 0.432033 Parvalbumin
HSD11B10.413042 0.538573 Hydroxysteroid(11-beta)dehydrogenase1
PHLDA20.452704 0.455578 Pleckstrin homology-like domain, family A

Downregulation of genes in each disease state is represented with negative FC values (fold decrease) and upregulation with positive FC values. Most statistical significant genes, common in SZ studies are differentiated in similar way.