Biologic Complexity in Sickle Cell Disease: Implications for Developing Targeted Therapeutics

Table 1

Major types of sickle cell intervention studies registered on the website http://www.clinicaltrials.gov/, as of December 1, 2012, of a total of 96 trials.

Pathway/mechanism	Number of studies
Bone marrow transplantation	21
Hemoglobin F induction	9
Nitric oxide related	8
Analgesic regimens	6
Nutritional supplements	4
Adhesion inhibition	3
Transfusion therapy	3
Red cell hydration	3
Noninvasive ventilation	3
Statins	2
Renin-angiotensin pathway in nephropathy	2
Iron chelation	2
Educational tools	2
Antiinflammation	2
Gene transfer	1
Carbon monoxide donation	1
Anti-coagulation	1