¹⁸F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns

Figure 3

Radiation therapy leads to profound growth inhibition of flank tumors. (a) BLI of bilateral flank xenografts at 0, 5, 12, and 20 days following unilateral 16 gray (Gy) radiation therapy (RT). Reduced surface radiance noted in RT tumors. (b) Comparison of changes in BLI Flux_max values in control (𝑛=3) and RT (𝑛=3) tumors. Reductions in Flux_max seen by 5 days after RT. (c) Comparison of change in %ID of ¹⁸F-FLT uptake in RT versus control tumors (𝑛=2) before RT and 2 weeks after RT. RT tumors demonstrate decreased uptake at 2 weeks.

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