Effects of Biochemical Alteration in Animal Model after Short-Term Exposure of Jatropha curcas (Linn) Leaf Extract

Table 3

Effects of methanolic leaf extract of J. curcas on plasma biochemical parameters of laboratory rats (𝑛=6, mean ± SD).

Parameter	Doses of extract (mg/kg body weight)
	Control	500	1000	2000
ALT (U/L)	21.03 ± 0.47^a	19.93 ± 0.83^ab	22.03 ± 0.93^ab	25.07 ± 1.85^a
AST (U/L)	19.05 ± 1.03^a	24.05 ± 0.93^a	25.47 ± 0.46^ab	24.93 ± 1.09^a
ALP (U/L)	43.03 ± 0.84^a	48.03 ± 1.03^a	45.04 ± 1.39^a	51.09 ± 3.04^a
GGT (U/L)	28.72 ± 3.29^a	29.54 ± 4.12^ab	30.60 ± 2.46^a	33.62 ± 3.01^ab
Albumin (mmol/L)	19.50 ± 0.85^a	19.12 ± 0.15^a	18.56 ± 1.74^a	17.31 ± 2.10^a
Total bilirubin (μmol/L)	12.53 ± 0.71^a	11.38 ± 0.21^a	11.01 ± 2.08^a	9.50 ± 0.53^a
Total protein (g/L)	6.07 ± 0.52^a	7.99 ± 0.62^b	5.80 ± 0.32^b	5.94 ± 0.46^a
BUN (mg/dL)	8.03 ± 2.01^a	10.90 ± 1.84^ab	9.91 ± 0.73^a	11.05 ± 1.89^b
Glucose (mmol/L)	5.59 ± 0.01^a	5.78 ± 0.01^a	5.71 ± 0.02^a	5.40 ± 0.20^a
Potassium (mmol/L)	6.95 ± 1.13^a	5. 52 ± 0.18^a	5.94 ± 0.15^a	5.96 ± 0.25^a
Sodium (mmol/L)	145.33 ± 2.51^a	146.52 ± 3.17^a	143.76 ± 0.68^a	141.98 ± 0.82^a
Chloride (mmol/L)	125.5 ± 3.52^a	110.45 ± 2.53^ab	98.51 ± 1.15^a	95.78 ± 1.58^a
Calcium (mmol/L)	5.54 ± 0.12^a	4.85 ± 0.01^a	5.01 ± 0.05^b	5.15 ± 0.04^a
Urea (mmol/L)	6.08 ± 0.21^a	7.89 ± 1.50^a	7.45 ± 0.58^a	6.50 ± 0.15^a
Creatinine (mmol/L)	0.56 ± 0.23^ab	0.73 ± 0.23^b	0.48 ± 0.35^a	0.66 ± 0.34^b
WBC count (×10^9/L)	16.20 ± 2.5^a	7.53 ± 1.60^b	9.02 ± 1.5^b	8.9 ± 2.4^b
Platelets (×10^9/L)	789.45 ± 5.84^a	734.01 ± 2.52^c	650.53 ± 7.89^c	645.32 ± 3.50^b
Basophils (%)	0.85 ± 0.51^a	0.55 ± 0.01^a	0.53 ± 0.21^a	0.50 ± 0.35^a
Monocytes (%)	27.56 ± 3.21^a	15.65 ± 4.50^c	12.89 ± 5.01^c	18.98 ± 2.51^b
Hg (g/L)	12.80 ±1.6^ab	10.04 ± 2.04^a	9.03 ± 2.09^ac	8.9 ± 1.76^ab
RBC (×10^9/L)	8.75 ± 0.05^a	9.84 ± 0.51^a	8.70 ± 0.53^a	8.45 ± 0.15^a
PCV (L/L)	0.50 ± 0.03^a	0.52 ± 0.2^bc	0.48 ± 0.02^ab	0.47 ± 0.04^ac
MCHC (g/dL)	29.50 ± 1.52^a	32.55 ± 0.52^a	31.81 ± 1.20^a	31.50 ± 0.51^a
LUC (%)	8.95 ± 1.05^a	10.25 ± 0.78^a	9.85 ± 1.07^a	8.45 ± 0.36^a

Means with the same letter are not significantly different (𝑃<0.05).
Legend: alanine transaminase (ALT); aspartate transaminase (AST); alkaline phosphatase (ALP); gamma glutamyl transferase (GGT); blood urea nitrogen (BUN); haemoglobin (Hg); pack cell volume (PCV); white blood cell (WBC); red blood cell (RBC); mean corpuscular haemoglobin concentration (MCHC); large unstained cell (LUC).